Patient demographics, the number of hospital admissions in the la

Patient demographics, the number of hospital admissions in the last 6 months of life, survival, and referrals to palliative care services were evaluated. Results: Ninety-eight patients were diagnosed with brain metastases and treated with WBRT alone. The median overall survival following WBRT was 80 days. Twenty-eight of the patients presented to the

emergency department bigger than = 2 times in the last 6 months of life. Sixty-eight percent of patients were referred to palliative care. Of those referrals, 57% selleck chemical were during an inpatient hospitalization. The median survival from palliative care referral to death was 27 days. Conclusions: Patients with brain metastasis requiring WBRT have a predictable dying trajectory. These patients are likely to have a high symptom burden and would benefit from palliative care. Timely palliative care referrals in this population remain RepSox molecular weight inadequate and classically follow a hospital admission. Referrals continued to be late in the dying process and the recommendation for WBRT can be used as an independent marker for initiating end-of-life discussions and involving palliative care.”
“Two phosphorus-based molecules were grafted onto flax fibers through electron beam irradiation in order to impart flame retardancy to flax fabrics. Fabrics were impregnated by dipping them into a solution containing a phosphonated

monomer: dimethyl(methacryloxy)methyl phosphonate (MAPC1) or dimethylvinyl phosphonate (MVP). Then fabrics were irradiated at a dose ranging between 10 and 100 kGy. The grafting efficiency was found to be Selleck CCI-779 dependent on the molecule concentration in the impregnation solution, on the radiation dose and on the nature of the monomer. In particular, it has been observed that MAPC1

is grafted only onto the surface while MVP is also grafted into the bulk leading to high phosphorus content (4 wt%). Flame retardancy of the modified flax fibers, fabrics and polyester thermoset composites containing these fabrics were also investigated. High phosphorus content allows fabrics to achieve self-extinguishing behavior. The flammability of composites in cone calorimeter test is also reduced, even if the thermoset is not flame retarded itself. (C) 2015 Elsevier Ltd. All rights reserved.”
“Objectives: To evaluate the effect of early versus deferred antiretroviral therapy (ART) on the neurodevelopment of infants from Cape Town participating in the Children with HIV Early Antiretroviral Therapy (CHER) trial.\n\nDesign: HIV-infected infants were randomized to early (<3 months) or deferred ART. HIV-uninfected infants (HIV-exposed and HIV-unexposed) provide background data.\n\nMethods: Neurological examination and Griffiths Mental Development Scales (GMDS) were administered between 10-16 months of age by testers blind to HIV status and randomized allocation. Mean quotients were compared using paired Student’s t-tests.

Initially imaging was carried

Initially imaging was carried https://www.selleckchem.com/products/gm6001.html out with plain x-ray, air encephalography, and angiography, and these techniques had a relatively minor role in epilepsy. Computerized tomographic (CT) scanning was introduced in 1971, and magnetic resonance imaging (MRI) a decade or so later, and both these technologies had an immediate and far-reaching impact on epilepsy. MRI techniques continued to evolve during the 1990s and profoundly influenced many aspects of epilepsy clinical practice. These structural imaging techniques revealed pathological lesions in large numbers of

patients with hitherto cryptogenic epilepsy, widened the indications for surgical therapy, and improved our understanding of the pathogenesis and etiology of epilepsy. In recent years, the research focus has turned to fMRI but its impact on epilepsy currently is relatively small. Magnetic resonance spectroscopy (MRS), positron emission tomography (PET) and single photon emission computed tomography (SPECT) also have had a limited impact on clinical practice in epilepsy.”
“Background: Studies have shown that red cell distribution

width (RDW) is related to outcome in chronic heart failure (CHF). The pathophysiological process is unknown. We studied the relationship between RDW and erythropoietin (EPO) resistance, and related factors such as find more erythropoietic activity, functional iron availability and hepcidin.\n\nMethods and Results: In the Mechanisms of Erythropoietin Action in the Cardiorenal Syndrome (EPO-CARES) study, which investigates the role of EPO in 54 iron-supplemented anemic patients with CHF and chronic kidney disease (CKD) (n = 35 treated with 50

IU/kg/wk Epopoetin beta, n = 19 control), RDW was not associated with EPO resistance. We defined EPO resistance by EPO levels (r = 0.12, P = .42), the observed/predicted log EPO ratio (r = 0.12, P = .42), the increase in reticulocytes after 2 weeks of EPO treatment (r = 0.18, P = .31), and the increase of hemoglobin after 6 months of EPO treatment (r = 0.26, P = .35). However, RDW was negatively correlated with functional iron availability (reticulocyte hemoglobin content, r = 0.48, P < .001, and transferrin saturation, r = 0.39, P = .005) and check details positively with erythropoietic activity (soluble transferrin receptor, r = 0.48, P < .001, immature reticulocyte fraction, r = 0.36, P = .01) and positively with interleukin-6 (r = 0.48, P < .001). No correlation existed between hepcidin-25 and RDW.\n\nConclusions: EPO resistance was not associated with RDW. RDW was associated with functional iron availability, erythropoietic activity, and interleukin-6 in anemic patients with CHF and CKD. (J Cardiac Fail 2011;17:626-633)”
“There has been considerable interest on cultivation of green microalgae (Chlorophyta) as a source of lipid that can alternatively be converted to biodiesel.

Here, we summarise the evidence for involvement of specific tyros

Here, we summarise the evidence for involvement of specific tyrosine kinases in the pathogenesis of IPF and the development of

tyrosine kinase inhibitors as treatments for IPF.”
“To date, the signal transducing adaptor molecule 2 (STAM2) was shown to harbour two ubiquitin binding domains (UBDs) known as the VHS and UIM domains, while the SH3 domain of STAM2 was reported to interact with deubiquitinating enzymes (DUBs) like UBPY and AMSH. In the present study, NMR evidences the interaction of the STAM2 SH3 domain with ubiquitin, demonstrating that SH3 constitutes the third UBD of STAM2. Furthermore, we show that a UBPY-derived peptide can outcompete ubiquitin for SH3 binding and vice versa. These results suggest that the SH3 domain selleck compound of STAM2 plays versatile roles in the context of ubiquitin mediated receptor sorting. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.”
“Maternal fish intake during pregnancy may influence the risk of child asthma and allergic rhinitis, yet evidence is conflicting on its association with

these outcomes. We examined the associations of maternal fish intake during example pregnancy with child asthma and allergic rhinitis. Mothers in the Danish National Birth Cohort (n 28 936) reported their fish intake at 12 and 30 weeks of gestation. Using multivariate logistic regression, we examined the associations of fish intake with child wheeze, asthma and rhinitis assessed at several time points: ever wheeze, recurrent wheeze (>3 episodes), ever asthma and allergic rhinitis, and current asthma, assessed at 18 months (n approximately 22 000) and 7 years (n approximately 17 000) using self-report and registry data on hospitalisations and prescribed medications. Compared with consistently high fish intake during pregnancy (fish as a sandwich or hot meal >= 2-3 times/week), never eating fish was associated with a higher risk of child asthma diagnosis at 18 months (OR 1.30, 95% CI 1.05, 1.63, P = 0.02), and ever asthma

by hospitalisation (OR 1.46, 95% CI 0.99, 2.13, P = 0.05) and medication prescription (OR 1.37, 95% Entinostat CI 1.10, 1.71, P = 0.01). A dose-response was present for asthma at 18 months only (P for trend 0.001). We found no associations with wheeze or recurrent wheeze at 18 months or with allergic rhinitis. The results suggest that high (v. no) maternal fish intake during pregnancy is protective against both early and ever asthma in 7-year-old children.”
“To evaluate roles of preoperative lymphoscintigraphy for sentinel lymph node biopsy in breast cancer patients.\n\nFive hundred and sixty-five consecutive breast cancer patients were prospectively randomized into groups with or without preoperative lymphoscintigraphy.\n\nIn a group with lymphoscintigraphy, 238 patients had sentinel lymph nodes spotted in lymphoscintigram.

The stringency of defining remission by the simplified disease ac

The stringency of defining remission by the simplified disease activity index when compared with other instruments was confirmed by ultrasonography. Sensitivity to change and similarity to clinical

assessments were shown for ultrasonographic indices; a simplified score for assessing joint damage by magnetic resonance imaging was presented. Physical function and working capacity continue to be impaired in the most recent decade. The evidence-based treat-to-target recommendations, NVP-LDE225 research buy developed by an international task force, are means to improve this situation. The American College of Rheumatology and the European League Against Rheumatism have most recently developed a stringent definition of remission for trials and practice.

Summary

The recent data provide compelling evidence for the importance of monitoring to attain the treatment targets in rheumatoid arthritis.”
“Personality

traits appear as determinants of quality of life (QoL) in most chronic diseases. The aim of this study is to explore whether neuroticism and extraversion contribute to the variance in QoL in patients with Parkinson’s Sapitinib disease (PD) when controlled for age, functional status and disease duration.

The Parkinson’s Disease Quality of Life Questionnaire (PDQ-39) was used to assess QoL and the Unified Parkinson’s Disease Rating Scale (UPDRS) for disease severity. Neuroticism and extraversion were measured with the Eysenck Personality Questionnaire (EPQR-A). Multiple linear regression NSC-732208 analysis was then used to assess the contribution of neuroticism and extraversion to QoL.

The sample consisted of 153 PD patients (48.4% women; 67.9 +/- A 9.3 years; mean disease duration 7.5 +/- A 5.8 years). Neuroticism was, after disease severity, the second most important variable associated with QoL in PD patients, in particular for domains associated with psychological processes: emotional well-being, social support, stigma and communication. A higher score in extraversion

was significantly associated with better emotional well-being in males, but surprisingly, with worse emotional well-being in females.

After functional status, personality traits were clearly associated with QoL in PD patients. Therefore, they should be taken into account by health-care professionals in their appraisal of patient complaints.”
“Construct subsidence is a relatively common complication following anterior cervical fusion. Its occurrence has been revealed to be closely related to endplate-implant contact interface. But current literature focusing on the anatomy of cervical endplate is very scarce. The purpose of this morphometric study was to analyse the sagittal geometry, especially the concavity and slope, of vertebral endplates from C3 to C7 by employing data from CT scans.

999 and the limits of detection (LD) and quantification (LQ) were

999 and the limits of detection (LD) and quantification (LQ) were 0.046 and 0.1 mu g/mL, respectively. Validation parameters, such as the specificity, linearity, precision, accuracy, and robustness were evaluated, and results were within the acceptable range. The results proved that the proposed method was successfully applied

to evaluate the entrapment efficiency and naringenin content in lecithin/chitosan nano-and microparticle suspensions.”
“Intrathoracic petechiae are a potential marker of acute asphyxia in stillborn infants. Retroplacental hematoma (RPH) is a cause of acute asphyxia. The histological features of Selleck 3-MA RPH can be timed using criteria for intrauterine duration of fetal death. Autopsies of stillborn infants of >26 weeks in gestation with RPH were evaluated for gross or microscopic evidence of petechiae. Placental gross and microscopic features were recorded. Eleven controls from other mechanisms of death were randomly selected. Intrathoracic petechiae

were present in all 17 infants with RPH of >50% of the placental area, in 3 of 7 infants with <50% area RPH, and in 2 of 11 infants with other diagnoses. The placenta demonstrated basal plate neutrophils in all cases of RPH (N = 21). Early coagulation necrosis in the villi overlying the RPH was present in 5 of 13 cases after 4 to 24 hours, and complete coagulation necrosis was present in 3 of 4 cases after 24 hours. Infants with RPH underlying >50% of Akt inhibitor the placenta demonstrate intrathoracic petechiae, but controls and infants with smaller RPH do so much less frequently. This is consistent with the hypothesis that intrathoracic petechiae are a marker for intrauterine asphyxia. Basal plate neutrophils are a useful early marker of retroplacental hemorrhage. Early coagulation necrosis of the placenta over RPH begins in 4 to 24 hours but is not complete after more than 24 hours.”
“Diffusivity of Er3+ into LiNbO3 crystal has been studied as a function of Li2O content and crystal orientation. The Li2O content in single-crystal LiNbO3 plates was adjusted by Li-rich vapor transport equilibration (VTE) technique.

Five VX-680 mw X-cut and five Z-cut congruent substrates were VTE treated at first at 1100 degrees C for different durations ranging from 6 to 74 h, and then were subjected to a special post-VTE anneal procedure at the same temperature for 60 h to obtain homogeneous Li2O content. The Li2O content was determined from the measured fundamental optical absorption edge. Its homogeneity is verified by measuring the optical absorption edge as a function of the crystal thickness. After the composition characterization, the substrates were coated with 45 nm thick Er film and annealed at 1130 degrees C for 40 h in argon atmosphere. The Er3+ profile was analyzed by secondary ion mass spectrometry. The results show that the Er3+ diffusivity decreases monoexponentially with the increase in the Li2O content in both cases of X- and Z-cut.

5 +/- 1 2) A group of 24 children without ADHD (normal children)

5 +/- 1.2). A group of 24 children without ADHD (normal children) were selected to match the children with ADHD on age and gender. The Movement Assessment Battery for Children, which includes three subtests, was used to assess the motor ability of the children of both groups. The Chinese version of Adaptive Behavior Scales, which consists

of 12 life domains, was used to assess adaptive function of the children with ADHD. Compared with the normal children, children with ADHD exhibited poorer motor ability on all the three subtests of motor assessment. In the ADHD group, nine (36%) children had significant motor impairments and seven (28%) were borderline cases. A total of 10 (40%) children with ADHD had definite adaptive problems in one or more adaptive domains. With statistically controlling of IQ for the ADHD group, those children with impaired motor ability had significantly poorer behaviors in the Autophagy inhibitor clinical trial adaptive domain of home living (p = 0.035). Moreover, children with ADHD who had severely impaired GSK461364 solubility dmso manual dexterity performed worse than the control group in the adaptive domains of home living (r = -0.47, p = 0.018), socialization (r= -0.49, p = 0.013), and self-direction (r = -0.41, p = 0.040). In addition, children with poorer ball skills had worse home living behavior (r = -0.56, p = 0.003). Children who had more impaired balance exhibited

poorer performance in social behavior (r = -0.41, p = 0.040). This study found significant correlation between motor ability and adaptive function in children with

ADHD, especially in their adaptive domains of home living, socialization, and self-direction. In clinical settings, identification of motor difficulties may have important implications for the understanding of relative factors in effective management BMS-754807 solubility dmso of the adaptive dysfunction in children with ADHD. Copyright (C) 2011, Elsevier Taiwan LLC. All rights reserved.”
“Objective. The aim of this study was the evaluation by using computerized tomography (CT) of craniofacial abnormalities in fibrodysplasia ossificans progressiva (FOP) patients regarding jaw restriction and retrognathia.

Study design. Seven FOP patients were evaluated retrospectively in this observational study. Inclusion criteria were detection of ACVR1 gene mutation and complete craniofacial CT examination. The age of jaw restriction and presence of retrognathia were clinically determined. The features analyzed were skull base structures and heterotopic ossification (HO).

Results. Of this group (age range 4-23 years), the 3 oldest patients presented with jaw restriction and retrognathia as well as displayed elongation of the lateral pterygoid plate with HO of the pterygoid muscles that reached the medial surface of the right mandibular ramus. They had significant history of trauma or surgery. The other 4 patients did not have retrognathia or HO involving the facial or masticatory muscles, and the mouth opening was normal.

Conclusions.

Therefore, it is recommended that a protective barrier be used ov

Therefore, it is recommended that a protective barrier be used over the canal filling to prevent leakage of bleaching agents. Glass-ionomer (GI) is commonly used as a coronal barrier before nonvital bleaching. Because mineral trioxide aggregate

(MTA) creates high alkalinity after mixing with water, using MTA as a protective CFTRinh-172 research buy barrier over the canal filling may not only prevent leakage of bleaching agents and microorganisms, but may prevent cervical resorption. The aim of this study was to evaluate sealing ability of white mineral trioxide aggregate (WMTA) as a coronal barrier before nonvital bleaching.

Study design: Root canals of one hundred thirty human maxillary incisors were instrumented and filled with gutta-percha without sealer. Gutta-percha was removed up to 3 mm below the cementoenamel junction (CEJ). The teeth were randomly divided into six experimental groups of 20 teeth each and two control groups of 5. In three experimental groups, WMTA was packed into the canal to the level selleck chemicals llc of CEJ. In the remaining experimental groups, glass-ionomer (GI) was used as a coronal barrier. After a 24-hour incubation period, one of the following three bleaching agents was placed in the access cavity of each of the WMTA or GI groups. These three

bleaching agents were 30% hydrogen peroxide, sodium perborate mixed with 30% hydrogen peroxide, and sodium perborate mixed with distilled water. The bleaching agents were replaced every 3 days for three times. In the positive controls,

no coronal barrier was used. In the negative controls, all the tooth surfaces were covered by two layers of nail varnish. Microleakage was evaluated using protein leakage test. Statistical analyses were performed with the Kruskal-Wallis and Mann-Whitney tests.

Results: The experimental groups showed minimum leakage which was not significantly more than tha in the negative controls. There was no statistically significant difference in leakage find more between the experimental groups (p<0.05).

Conclusions: This study indicated that different bleaching agents have no effect on sealing ability of WMTA.”
“An 8-year-old boy developed a large aneurysm of the aortic arch after neonatal complete repair of interrupted aortic arch type B and closure of a perimembranous ventricular septal defect. To our knowledge, this unusual complication has not been previously reported in the English literature.”
“In 2011, the Division of Violence Prevention (DVP) within CDC’s Injury Center engaged an external panel of experts to review and evaluate its research and programmatic portfolio for sexual violence (SV) prevention from 2000 to 2010. This article summarizes findings from the review by highlighting DVP’s key activities and accomplishments during this period and identifying remaining gaps in the field and future directions for SV prevention.

6 y) were enrolled in this Phase 1 dose-finding study Patients r

6 y) were enrolled in this Phase 1 dose-finding study. Patients received ch14.18/CHO courses of 10, 20 or 30 mg/m(2)/day as an eight-hour infusion over five consecutive days. Three courses at the same dose level were allowed unless disease progressed. Clearance and biodistribution of radiolabelled ch14.18/CHO in Balb/c and A/J mice were analyzed. Results: A total of 41 ch14.18/CHO courses were given (10 x 3 courses, 5 x 2 courses, 1 x 1 course). Side effects were similar in expectedness, frequency and magnitude to those reported for ch14.18/SP2/0. The dose level of 20 mg/m(2)/day was confirmed. Toxicity was reversible and no CHIR98014 in vivo treatment-related deaths occurred. In

children, the peak plasma

concentration was 16.51 mu g/ml 5.9 mu g/ml and the half-life was 76.91 h +/- 52.5 h. A partial response following ch14.18/CHO was observed in 2/7 patients with residual disease. In mice, the half-lives were 22.7 h +/- 1.9h for ch14.18/CHO and 25.0 h +/- 1.9 h for ch14.18/SP2/0. The biodistribution of I-125-ch14.18/CHO in mice with neuroblastoma was identical to I-125-ch14.18/SP2/0, indicating GD(2) targeting activity in vivo.

Ch14.18 produced in CHO cells showed an unchanged toxicity profile and pharmacokinetics in neuroblastoma patients compared with ch14.18 produced in SP2/0 cells, and evidence of clinical activity was observed. In mice, analysis of pharmacokinetics and biodistribution showed comparable results between ch14.18/CHO and ch14.18/SP2/0. Based on these results, ch14.18/CHO was accepted for prospective clinical evaluation.”
“Prevention of mother-to-child transmission

learn more GSK1120212 nmr of HIV and Toxoplasma dual infections in the immunocompromised patient remains a healthcare challenge. We report a case of congenital toxoplasmosis resulting from reactivation of latent infection in a severely immunodepressed HIV-infected pregnant woman, who had poor adherence to therapy; this case illustrates the difficulties encountered in management of such a rare condition.”
“Three new flavonol glycosides, sarmenosides V-VII (1-3), were isolated from the whole plant of Sedum sarmentosum (Crassulaseae). The structures of 1-3 were determined on the basis of spectroscopic analysis. Among the flavonoid constituents from S. sarmentosum, 1 and 3 were found to show oleic acid-albumin-induced lipid accumulation inhibitory activity. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.”
“Objective: The aim of this study is to evaluate whether closure of a tympanic membrane perforation with an intact ossicular chain results in a closure of the air-bone gap.

Study Design: Prospectively collected data from 154 patients undergoing temporalis fascia myringoplasty for chronic otitis media simplex were identified.

Setting: Tertiary referral center.

Cytotoxicity

seemed to be unaffected by the PM biogenic c

Cytotoxicity

seemed to be unaffected by the PM biogenic components, while inflammation was significantly reduced after the inhibition of some biogenic activated pathways. Besides, the PM-associated biogenic activity does not entirely justify the PM-induced inflammatory effects. (C) 2010 Wiley Periodicals, Inc. Environ Toxicol 2012.”
“Stress clearly influences decision making, but the effects are complex. This review focuses on the potential for stress to promote prosocial decisions, serving others at a temporary cost to the self. Recent work has shown altruistic responses under stress, particularly when the target’s need is salient. We discuss potential mechanisms for these effects, including emotional contagion and offspring care mechanisms. These neurobiological mechanisms may promote prosocial-even heroic-action, particularly when an observer knows the appropriate response and can respond to a target in need. Selleckchem CA4P The effects of stress on behavior are not only negative, they can be adaptive and altruistic under conditions that promote survival and well-being at the individual and group level.”
“The aim of this retrospective study was to determine the relevance

of the symptom “”headache”" in kidney transplanted patients, since few studies have considered headache as a clinically significant complication in this condition. A total of 83 consecutive kidney transplant patients underwent to CBL0137 cost neurological examination and a detailed headache history was taken. The headache history considered the period before kidney disease, during renal failure, during dialysis treatment and after Smoothened Agonist concentration transplantation. Diagnosis was made according to International Headache Criteria (ICDH-II) (2004). Our results reveal an occurrence of headache after kidney transplantation in 44.5% of the patients, which is higher than rates reported for the general population and in the only specific comparable study on liver transplant patients. These data suggest

the need for prospective studies to explore the causal mechanisms by which headache develops with frequency in kidney transplant patients, and in particular to determine the role of immunosuppressive therapy.”
“The use of mussel extracts in in vitro bioassays which express the estrogen receptor could provide valuable information on the bioavailability of endocrine disruptors in coastal environments. The aim of this study was to assess the temporal variability of the estrogenic responses in bioassays in Mytilus galloprovincialis. A 6-month in situ experiment was conducted in order to follow the estrogenic activity on MELN cell line during the reproduction stages of mussels. Estradiol equivalents (EEQ) determined in mussels using the MELN cell lines ranged from 0.79 to 3.72 ng/g dry weight (d.w.) in males, from 0.42 to 2.33 ng/g d.w. in females and from 3.41 to 4.2 d.w. in undifferentiated bivalves.

Of 112

Of 112 Selleckchem Milciclib patients, 28 (25%) underwent fascial anchoring, and 84 (75%) received tined leads. Within 2 years of implantation, lead migration occurred in 26% of fascial and 10% of tined anchoring systems (RR, 2.25 (95% confidence interval, 0.85-5.93)). Patients with fascial anchors were followed for a longer period of time. Therefore, Kaplan-Meier curves were compared showing no difference in risk of lead migration (p = 0.09). Four of eight (50%) lead migrations in tined leads occurred within the first 3 months after implantation.

Two years after sacral neuromodulator implantation, lead migration is similar between

fascial-anchored and tined leads.”
“Epitaxial thin films of biferroic (Bi1-xLax)(2)NiMnO6 have been grown on SrTiO3 (001) substrates. High resolution electron microscopy, energy-loss spectroscopy and synchrotron radiation have been used to demonstrate that, under appropriate growth conditions, stoichiometric, and fully oxidized thin films with long-range

order of Ni2+ and Mn4+ ions can be obtained, despite the presence of randomly distributed dissimilar cations (Bi, La) at the A-site. This ordering leads to Ni2+-O-Mn4+ ferromagnetic interactions and its preservation in thin films is key for implementation of these biferroic materials in practical devices. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3524278]“
“Purpose To compare the induction of double-strand breaks (DSB) in cells irradiated by 250 Ulixertinib research buy and 350 CV ultrasoft X-rays and assess the residual yield of breaks 2 hours post irradiation in order to unravel Fer-1 the correlation between the sharp increase in cell-killing efficiency of ultrasoft X-rays above versus below the carbon-K threshold (284 eV) and the induction of core events in DNA atoms

Materials and methods. V79-4 hamster cells were irradiated with synchrotron ultrasoft X-rays at isoattenuating energies

of 250 eV and 350 eV DSB were quantified using Pulse field gel electrophoresis Results A significant increase in DSB induction was observed for 350 CV ultrasoft X-rays above the carbon-K threshold, compared to 250 eV below the threshold, per unit dose to the cell. The DSB induced by the 350 eV ultrasoft X-rays were less repaired 2 h after irradiation

Conclusion The increased DSB induction at 350 eV is attributed 10 the increase In the relative proportion of photon interactions in DNA resulting in significant dose inhomogeneity across the cell with a local increase in dose to DNA It results from all increase in carbon-K shell interactions and the short range of the electrons produced Core ionisations in DNA, through core-hole relaxation in conjunction with localised effects of spatially correlated low-energy photo- and Auger-electrons lead to an increase in number and the complexity of DSB.”
“In this paper, localized surface plasmon resonance (LSPR) effects by naturally occurring Chinese yam particles are observed and quantified.