Transistors based on this concept could be realized
on different layers, on the same substrate, with technologies similar to those actually used for conventional integrated circuits: this would make possible an effective three-dimensional integration of devices and circuits.”
“Percolation theory has been applied to study the drug release behaviour in multicomponent inert matrices containing ethylcellulose as a matrix forming polymer. Global influence of major formulation factors such as polymer viscosity, polymer particle size, drug and filler solubility and porosity of the tablets in drug release kinetics has been studied for the first time. Batches containing three viscosity grades of Ethocel (TM), microcrystalline cellulose (MCC) and lactose as fillers, EGFR inhibitor drugs a lubricant and flow aid mixture and three drugs with different solubility have been manufactured. For some batches, compression pressure was varied in order to obtain matrices with five levels of initial porosity The behaviour of inert matrices was explained based on the percolation ranges of the main components of the formulation. The effect of the Tideglusib in vivo porosity percolation threshold was observed and the existence of a tricoherent drug-polymer-filler system is hypothesized.”
“Objective: The goal of the study described here was to obtain psychometric validation
of the Spanish version of the 38-item Side Effects and Life Satisfaction (SEALS) Inventory.
Methods: A cross-cultural adaptation of the inventory was performed. A total of 595 patients with epilepsy were included in a multicenter cross-sectional study. The SEALS Inventory was completed, together with the Hospital Anxiety and Depression Scale and SF-12 Health Survey.
Results: The mean SEALS score was 60.7. SEALS presented high internal consistency, with a Cronbach alpha coefficient of 0.93, and good test-retest reliability, with an intraclass correlation coefficient of 0.92. The pattern of correlations with the Hospital DMXAA in vivo Anxiety and Depression Scale and SF-I 2 Health Survey indicated good convergent and divergent validity.
SEALS scores discriminated patients according to epilepsy-related factors, emotional disturbances, and the generic quality of life.
Conclusion: The Spanish version of the SEALS Inventory is a valid psychometric instrument. It may be used in routine clinical practice and in clinical trials in patients with epilepsy to capture the cognitive and behavioral aspects of quality of life. (C) 2008 Elsevier Inc. All rights reserved.”
“As disparities in healthcare between the industrialized world and low- and middle-income countries (LMIC) continue to widen, novel methods of delivering cardiovascular therapies-specifically electrophysiological devices-must be explored. Post-mortem pacemaker donation is a safe and effective method of decreasing the morbidity associated with cardiovascular disease in LMIC.