The monkeys were trained to perform a sequential delayed non-matc

The monkeys were trained to perform a sequential delayed non-matching-to-sample (DNMS) task that requires discrimination of faces, face-like schematics and simple patterns (Fig. 1). The task was initiated by a buzzer tone; then, a fixation cross appeared on the center of the display. When the monkeys fixated on the cross for 1.5 s, a sample stimulus was presented for 500 ms (sample phase). The control phase was defined as the period of 100 ms before the sample phase. When facial photos were used as sample stimuli, gaze directions

of the stimuli were either directed to or averted from the monkey. Then, after an interval of GSI-IX solubility dmso 1.5 s, the same stimulus appeared again for 500 ms, between one and four times (selected randomly for each trial). Finally, a new stimulus with different gaze direction was presented (target phase). When the target appeared, the monkey was required

to press a button within 2 s to receive a juice reward (0.8 mL). When the monkey failed to respond correctly during the target phase or press the button before the target phase, the trials were aborted and a 620-Hz buzzer tone was presented. The inter-trial intervals were 15–25 s (Fig. 2). In the DNMS task, the monkey compared a pair of stimuli in each trial (i.e. sample and target stimuli). Stimulus pairs consisted of the same category of stimuli; only pairs of facial stimuli and pairs of geometric patterns were used check details (i.e. facial stimuli were not paired with geometric patterns). In the facial pairs, averted gazes were always paired with directed gazes; stimulus pairs of gazes averted to the left and the right were not used. Furthermore, the facial stimuli presented in the target phase were the same as in the comparison phase, apart from gaze direction (i.e. same model and same head orientation); thus, the monkeys were required to detect a difference in gaze direction

(directed vs. averted gaze). For the geometric patterns selleck (Fig. 1B), only stimuli within the same category (cartoon faces, face-like patterns, eye-like patterns and simple geometric patterns) were paired. Thus, a total of 72 stimulus pairs (for each of the five models – frontal faces, four pairs; profile faces, four pairs; cartoon faces, four pairs; face-like patterns, 12 pairs; eye-like patterns, four pairs; simple geometric patterns, 12 pairs) were used. These procedures facilitated the monkeys in learning that a shift in gaze direction was an important clue for solving the task. The monkeys were trained in the DNMS task for 3 h/day, 5 days/week. The monkeys required about 11 months of training to reach a 97% correct-response rate. After completion of this training period, a head-restraining device (a U-shaped plate made of epoxy resin) was attached to the skull under aseptic conditions (Nishijo et al., 1988a,b; Tazumi et al., 2010).

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