The BM mononuclear cells showed 764 up regulated and 1,910 down regulated genes in RA patients relative on the OA group. EASE revealed the gene category response Topoisomerase to external stimulus, which incorporated the gene category immune response, was overrepresented by the up regulated genes. So also were the gene classes signal transduction and phosphate metabolism. Down regulated genes were dominantly classified in three gene categories: cell proliferation, which integrated mitotic cell cycle, DNA replication and chromosome cycle, and DNA metabolism. Most genes in these classes overlapped with one another. IPA analysis showed that the up regulated genes in immune response were really related towards the antigen presentation pathway and to interferon signaling.

The key histocompatibility complex class I molecules, HLA E, HLA F, and HLA G, tapasin and TAP binding protein, each of that are involved in peptide antigen binding and presentation by means of MHC class I molecules, are depicted during the immune response molecule networks. Interferon gamma and interleukin 8 have been overexpressed and uncovered to perform specific PDK1 inhibitor central roles in these networks. Conclusions: Abnormal regulatory networks while in the immune response and cell cycle classes have been identified in BM mononuclear cells from RA patients, indicating the BM is pathologically concerned in RA.

P40 Risk things for latent tuberculosis infection in RA sufferers taken care of with anti tumor necrosis element Shiang Fen Huang1, Wei Juin Su1, Sheng Yuan Ruan2, Chong Jen Yu2, Song Chou Hsieh3, Yu Chih Liu4, Yeong Jian Jan Wu5, Hsiao Yi Lin6 1Department of Chest Medication, Taipei Veterans Common Hospital, School of Medicine, Nationwide Cholangiocarcinoma Yang Ming University, Taipei, Taiwan, 2Division of Pulmonary and Crucial Care Medication, Division of Internal Medicine, Nationwide Taiwan University Hospital, Taipei, Taiwan, 3Division of Allergy, Immunology and Rheumatology, Division of Inner Medication, National Taiwan University Hospital, Taipei, Taiwan, 4Department of Medicine, Division of Pulmonary Medication, Chang Gung Memorial Hospital, Keelung, Taiwan, 5Department of Medicine, Division of Allergy, Immunology and Rheumatology, Chang Gung Memorial Hospital, Keelung, Taiwan, 6Division of Allergy, Immunology and Rheumatology, Division of Medicine, Taipei Veterans Basic Hospital, Taipei, Taiwan E mail: syruan@ntu. edu.

tw Arthritis Investigate & Therapy 2012, 14 40 Background: To estimate the prevalence of latent tuberculosis infection according to the interferon HIF inhibitors gamma release assay in sufferers with rheumatoid arthritis, and assess the possibility components for incidence of active TB after TNF alpha blocking agents treatment. Methods: A multicenter, prospective, and observational study was started in April, 2011 for patients with RA in Taiwan University Hospital, Taipei Veterans General Hospital, and Chang Gung Memorial Hospital in Keelung. Individuals who take anti TNFa regiments or not were each enrolled while in the study.