Reduced amount of Atherosclerosis by CETP Inhibition and HDL Elevation research is evaluating the effects of the same treatment regimens on atherosclerotic progression in coronary arteries within the greatest intravascular ultrasound test ever performed. As well as the therapeutic techniques targeted at raising HDL cholesterol levels, many novel agents target the inflammatory components PF299804 ic50 of atherosclerosis and acute coronary syndromes with the goal of reducing cardio-vascular events. The Aggressive Reduced total of Inflammation Stops Events test is evaluating a synthetic antioxidant that is structurally related to probucol in significantly more than 6000 patients with recent acute coronary syndromes. Furthermore, other anti inflammatory substances are now being tried, including those that target the serine protease inhibitors and phospholipase A2 and leukotriene pathway. The anti-obesity agent rimonabant can also be contained in this type, and has been evaluated in imaging and clinical end point tests, since adipose tissue is an essential source of proinflammatory mediators. While new pharmacological methods Cellular differentiation bear potential to induce atherosclerosis regression and provide medical benefits, some other important dilemmas represent prevention challenges. While statins and antihypertensive drugs have demonstrated an ability to lessen cardiovascular functions in randomized clinical trials, the rates of nonadherence to therapy remain high within the clinical setting, thus limiting the real preventive influence of such medication. In addition, the development of powerful pharmacological agents is happening paradoxically at any given time when we are confronted with a lack of physical exercise in our society and alarming problems of harmful eating habits. It is important that clinicians take the necessary time to go over lifestyle changes using their people, both in the primary and secondary prevention settings. The p53 ubiquitination Lyon Diet Heart Study offered very encouraging and provocative results, showing rapid and essential reductions in recurrent cardiovascular events in men with previous myocardial infarction have been taught to consume fruits each day, more root and green vegetables, more fish, more bread and less meat, to replace butter and cream with canola margarine, and to utilize rapeseed and olive oils in cooking. RESULTS While statins have allowed entry into the era of atherosclerosis regression, the health care system is confronted by a growing population at risk for future events and a growing frequency of cardiovascular infection. The additional cardio-vascular protection needed for patients with atherosclerosis is likely to be centered on novel treatments that rise above LDL-CHOLESTEROL reduction and that are presently being evaluated. Atherosclerosis is a systemic infection that affects many vascular beds.