Neurosci Lett 2010, 472:184 187. P7 Frequency of physical appearance of anemias at rheumatoid arthritis a condition of autoimmune genesis Abdumalik N Aripov1, Marif SH Karimov2, Aida A Eshmurzaeva2 1Tashkent Institute of Postgraduate Wnt Pathway Health-related Education, Tashkent, Uzbekistan, 2Tashkent Health-related Academy, Tashkent, Uzbekistan Arthritis Investigation & Therapy 2012, 14 7 The purpose of exploration is study of offenses of physical appearance of anemia among rheumatoid arthritis patients, revealing of their etiologic reasons, as well as the estimation of character of used anti anemia means of medicine on the basis of retrospective analysis of history of ailment. Coming out of above stated histories of illness of RA patients were analyzed to presence of established as accompanying condition of anemia.

Results of this analysis are represented on picture as it seen on the presented data, 33,3% of patients with RA anemia is verified as accompanying pathology. Therefore at 1/3 patients with P anemia takes place. The study of etiologic causes of anemia at these patients shows Natural products supplier that in 76,6% cases anemia bears ferrous deficit character, 20% anemia of chronic diseases and only in 3,4% cases auto immune anemia. Therefore, the majority of patients of RA anemia bears ferrous deficit character. The high frequency of appearance of ferrous deficit anemia among RA patients, probably is explained by that in conditions of this condition changes of pH happen among gastro duodenal area. Besides, wide use of non steroidal anti inflammatory medicine at RA also may effect to pH of stomach.

And Chromoblastomycosis in cases of destroyed reaction of ambience change of ferrous assimilation. That fact of ferrous deficit anemia may has independent character at analyzed RA patients is excluded. But on their history of illness it is impossible to determine this fact. Study of offenses of appearance of anemia at RA patients depending on age categories is evidencing on that 83,4% of patients with anemia comes to patients from 31 to 60 years old, and among patients of 31 to 40 years old appears 25% patients, from 41 to 50 years old 26,7% and from 51 to 60 years old 31,7%, accordingly. Results of these analysis showed that if at patients with debut RA anemia appears at 1,5% cases, than among RA patients with prolongation of anamnesis from 1 to 5 years old, from 5 to 10 years old appears in 33,3%, 28,7% and in 34,8% cases accordingly.

Therefore as far as increasing of prolongation of current of RA, specific gravity of patients with anemia increases. bcr abl protein P8 The bacterial effector protein YopM reduces rheumatoid arthritis outcome by inhibiting inflammation and bone destruction J Bertrand1, C Rueter2, C Cromme3, J Scharnert2, A Schmidt2, T Pap3 1Experimental Medicine and Rheumatology, William Harvey Research Institute, London, UK, 2Institute of Infectiology, ZMBE, Muenster, Germany, 3Institute of experimental musculoskeletal medicine, University hospital Muenster, Muenster, Germany Arthritis Exploration & Therapy 2012, 14 8 Osteoclasts mediate the degradation of bone during RA and are derived from macrophages. The yersinia outer protein M is an effector Page 22 of 54 protein of Yersinia species that is able to enter host cells by membrane penetration. In the cell YopM mediates down regulation of inflammatory responses.