multiflorum R. rosea, and with the read what he said highest phenolic content were in P. cuspidatum R. rosea P. multiflorum. Comparison of the data from the antioxidant capacity Inhibitors,Modulators,Libraries assays with those from the staurosporine assay suggested that they appeared to be correlated. Correlation analysis confirmed the strong correlation with the correlation co efficient equal to 0. 93, 0. 80 and 0. 81 respectively. The data suggest that the neuroprotective activity of these herbal extracts was correlated with their antioxidant capacity and phenolic content determined in non cellular assays. Interestingly, however, the P. multiflorum and R. rosea extracts proved to be the exception as they exhibited a high level of anti oxidant capacity in all three assays, but did not exhibit neuroprotective effects in the cell based assay.

These re sults suggest that high antioxidant activity alone is not a predictor of cytoprotective activity and the mechanistic contribution of antioxidant effects of plant secondary metabolites needs to be established on a case by case basis. It is possible that antioxidant Inhibitors,Modulators,Libraries effects of plant derived compounds are merely epiphenomena. easily assayed but not necessarily biologically relevant. Conclusion The results from this study demonstrate that G. lucidum, G. glabra, S. chinensis and P. cuspidatum significantly pro tected primary cortical neurons from staurosporine in duced cell death. The neuroprotective effects of the P. cuspidatum extract appeared to be predominantly due to its major ingredient, resveratrol, but were more effective based on equivalence of resveratrol concentrations.

The neuroprotective activity of these herbal extracts was correlated with their antioxidant capacity. Interestingly, some extracts exhibited selective protection in neurons but not glia or glia but less so in neurons. Together, the data appear to support the traditional practice of combining multiple herbal medi Inhibitors,Modulators,Libraries cines for the treatment of complex disorders. Our findings provide experimental evidence that jus tify future in vivo studies to lay the ground for or finally refute the scientific Inhibitors,Modulators,Libraries and rational use of this category of herbal medicines to promote healthy aging. At present, however, caution is warranted as some herbal medicines may in fact exhibit neurotoxic effects. Background The most frequently occurring cancer in women, and the second leading cause of cancer death among women, is breast cancer.

Cancer results from cellular mutations that enhance proliferation, decrease anti proliferative signals, and decrease programmed cell death. and from cellular alterations that enhance angiogenesis and Inhibitors,Modulators,Libraries metastasis. Members of the Wnt family of secreted proteins regulate cellular proliferation, morphology, and migration selelck kinase inhibitor by way of catenin mediated transcriptional activation. Inappropriate activation of the Wnt catenin pathway, which results from mutations in several downstream genes, contributes to the genesis of a wide range of human cancers.