Methods: We compared cortisol responses to tetracosactide (250 mu

Methods: We compared cortisol responses to tetracosactide (250 mu g) between NCCAH patients and a comparison group

(CG) of patients with premature pubarche and normal tetracosactide test. An adequate cortisol response was defined as a peak bigger than = 18 mu g/dl. Results: We included 35 NCCAH patients (26 girls, 9 boys), whose mean age at testing was 7.0 years (0.8-15.6), click here and 47 patients in the CG (39 girls, 8 boys), whose mean age was 7.2 years (0.5-9.9). Baseline cortisol was significantly higher in the NCCAH group than in the CG [12.9 (4.3-22.2) vs. 9.7 (4.2-16.2) mu g/dl, respectively; p = 0.0006]. NCCAH patients had lower cortisol peak response compared to the CG [18.2 (6.3-40) vs. 24.9 (12-30.3) mu g/dl, respectively; p smaller than 0.0001]. Peak cortisol was smaller than 18 mu g/dl in 21/35 (60%) NCCAH patients versus 1/47 (2.1%) in the CG. No NCCAH patients had acute adrenal insufficiency, but 2 reported severe fatigue that improved with hydrocortisone. Conclusions: The cortisol response to tetracosactide was inadequate ( smaller than 18 mu g/dl) in 60% of patients with NCCAH. Hydrocortisone therapy may deserve consideration when major stress (surgery, trauma, childbirth) or objectively documented fatigue occurs

in NCCAH patients with inadequate cortisol response. (C) 2015 S. Karger AG, Basel”
“Interpersonal curiosity (IPC) is an important intrinsic motivation in social interaction, yet studies focused on its neural mechanism are rare. In a three-agent (Self, Other, or Computer) interactive gambling task, we recorded event-related BEZ235 concentration potentials (ERPs) to a cue stimuli indicating whether participants will be informed of their own, of another participant’s or the computer’s outcomes such that curiosity will be satisfied (CWS) or curiosity will not be satisfied (CWN). The results showed that relative to the CWS cue stimuli the CWN cue evoked a larger late positive component (LPC) between

approximately 400 ms and 700 ms after cue onset in both the Self and Other conditions, but not in the Computer condition. LY2835219 in vivo Additionally, participants reported stronger curiosity in the Other’s outcomes than in the Computer’s outcomes. Most importantly, participants’ subjective rating of curiosity was significantly correlated with the amplitude of the LPC elicited by the CWN cue. Furthermore, scores in the “curiosity about emotion” subscale of the IPC Scale was significantly correlated with the LPC amplitude when the participants learn they will not be informed of the Other’s outcomes. We suggest that (1) interpersonal information is of great significance to individuals and IPC is an important social motivator, and (2) LPC amplitude is sensitive to IPC. (C) 2013 Elsevier B.V. All rights reserved.

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