In June 2010, the SVS Board of Directors approved a set of guidelines specifically designed to address management of conflict of interest among its members and its leaders. These guidelines, included in this article, were based

on currently available information and policies put forth by legislative bodies, academic medical centers, industry groups, and other professional medical societies, and were designed to safeguard against abuse while maintaining valuable collaboration between vascular surgeons and their industry partners. The guidelines are included in this article. (J Vase Surg 2011;54:3S-11S.)”
“Cerebellar granule cells undergo profound and rapid morphological modifications during development while they migrate from their birthplace at the surface of the cerebellar cortex to its deepest layer. buy A-1331852 Post-mitotic granule cells extend bipolar axons and sequentially use the two main modes of migration, tangential and radial, to reach their final destinations. Recent studies show that protein degradation involving key cell-cycle regulators controls granule cell axon extension. The use of knockout mice deficient in different axon-guidance molecules combined with cutting-edge imaging methods has started to shed light on the molecular mechanisms that trigger granule

cell migration. These studies suggest that a major reorganization of the cytoskeleton occurs as granule cells switch from tangential to radial migration.”
“Psychotic depression is classified as a clinical subtype of major depressive disorder. The combination CA3 in vitro of an antidepressant with an antipsychotic agent has been demonstrated to be efficacious for the treatment of psychotic depression. However, in elderly patients with psychotic depression, little information is available on the efficacy of such combinations. Therefore, we have evaluated combination treatment for 5 weeks with amisulpride and antidepressants in non-demented elderly patients with psychotic depression. Eleven patients

were treated with methylhexanamine either citalopram 20-40 mg/day (n = 5) or mirtazapine 30-60 mg/day (n = 6), and amisulpride 75-100 mg/day for 5 weeks. Clinical status was evaluated at baseline and after 3 and 5 weeks using the Brief Psychiatric Rating Scale (BPRS), the Hamilton Depression Rating Scale-17 items (HDRS) and the Clinical Global Impression Scale (CGI-S). In 5 of the 11 patients there was remission of depression, while in another 5 patients there was partial remission of depression and in one patient there was no remission. Finally, there was resolution of psychotic symptoms in all the patients involved. One patient developed tremor and rigidity but insisted on continuing with the drug since her psychopathology has improved considerably after the addition of amisulpride to antidepressant treatment.