Countries of Southeast Asia, Japan, South Korea and China have noted a high incidence of gastric JNJ-26481585 cancer (14,15). The overall incidence of gastric cancer in India is less compared to rest of the world (4-6). However, certain regions of India have recorded a high incidence, especially the north eastern states like Mizoram (6). In North-East region very high incidence of all sites of cancers in general and tobacco

related cancers in particular have been reported. Inhibitors,research,lifescience,medical Pattern of tobacco use is noted to be different in North-East region. The genetic susceptibility of cancer due to ethnic variation related to polymorphism and mutation in autosomal recessive genes has been suspected. Certain dietary and tobacco related carcinogens are known to act as co-factors to bring out genetic changes (16). A high incidence of gastric cancer has also been reported in the state of Manipur, where it constitutes the second most common malignancy among males. There is lack of clinic-pathological information Inhibitors,research,lifescience,medical about gastric cancer from Manipur. In

our study, the peak incidence of gastric cancer was in age group older than 60 years old (42.4%). Also male predominance was noted with male to female ratio of 2.16:1, which are comparable with other studies (17-21). Presumably, this male preponderance could be attributed to the high incidence of smoking (67.6%) found among the males, with male to female smoking Inhibitors,research,lifescience,medical ratio of 3.3:1 in our study. About 7.6% of patients in our study had a positive family history which was similar to another study (17). However, many other studies have reported a positive family history

of 17% of patients (22). Our low estimate of family history could have been Inhibitors,research,lifescience,medical because of poor reporting by patient attendees. An overwhelming majority of patients Inhibitors,research,lifescience,medical (77.8%) in our study had a history of consumption of smoked meat, and 67.7% of patients had history of consumption of dried, fermented fish. Whereas, only 27.8% of the patients had a history of regular consumption of fresh fruits. Consumption of dried fish has found to increase the risk of gastric cancer (23). It is also well known that high consumption of smoked meat and decreased consumption of fresh these fruits increases the risk of gastric cancer (8,9). The most common presenting symptoms in our study abdominal pain (61.4%) and weight loss (59.5%), which were similar to other studies (17,24). Our findings revealed that most common site of tumour was antrum (57.45%) followed by cardia (17.1%) which are consistent with many other studies (25-28). However, increased incidence of tumour occurrence in gastro-esophageal junction has been noted in many western studies (27). Considering the histological type, majority (95.6%) were found to be adenocarcinoma consistent with other studies (17,29). Majority of the tumours (44.3%) in our study were poorly differentiated, similar to other studies (17,30).