Conclusion: AKI post-CC carries a worse prognosis with
higher adverse Talazoparib price event rates at year 2. Significantly, transient AKI also carries similar prognosis as those who had persistent AKI and effort should be made to monitor this group closely. WU VIN-CENT1, WU PEI-CHEN2, WU CHE-HSIUNG3, HUANG TAO-MING4 1National Taiwan University Hospital; 2Internal Medicine, Da -Chien General Hospital; 3Buddhist Tzu-Chi General Hospital, Taipei Branch; 4National Taiwan University Hospital, Yun-Lin Branch Introduction: The incidence of dialysis-requiring acute kidney injury (AKI) in hospitalized patients is increasing, but knowledge of long-term incident stroke of patients surviving to discharge after dialysis-recovered AKI is not elucidated. Methods: Patients that survived after recovery from dialysis-requiring AKI during index hospitalization from 1999 to 2008 were identified in nationwide administrative registries. The risk of de novo stroke and death were analyzed with time-varying Cox GSI-IX nmr proportional hazard models. The result was validated by a prospective collecting database. Results: After a serial selection from a total of 42,862 adult patients with AKI and dialysis, we enrolled 4,315 patients as the AKI-recovery group (men, 57.7%; mean age, 62.8 ± 16.8 years) and matched 4,315 control subjects as the non-AKI group by propensity scores. After a median follow-up
period of 3.36 years, subsequent incident stroke was 15.6 per 1,000 person-years. The AKI-recovery group had a higher risk (hazard ratio (HR), 1.25, p = 0.040) and higher severity for stroke events than the non-AKI group, regardless of progression to subsequent chronic kidney disease. The ratio of incident stroke was similar in those with diabetes alone (without AKI) and in those with AKI alone (without DM) after hospital discharge (p = 0.086). Furthermore, the AKI-recovery
group was more likely to die than non-AKI patients (HR 2.4, 95% CI 1.6–2.4; p < 0.001). Conclusion: Recovered AKI had higher incidence of developing incident stroke and mortality than patients without AKI and its impact is similar to diabetes. Our results suggest that a public health initiative is needed to enhance post-discharge follow-up of renal function, and control subsequent Mannose-binding protein-associated serine protease stroke among the patients with dialysis-recovered AKI. GOJASENI PONGSATHORN, THAMMANIRAMOL GUNYAMOL, CHUASUWAN ANAN, PAKCHOTANON KOLASORN, CHITTINANDANA ANUTRA Bhumibol Adulyadej Hospital, Directorate of Medical Services, Royal Thai Air Force Introduction: KDIGO guideline recommends delivering a Kt/V of 3.9 per week when using intermittent RRT in acute kidney injury. In Thailand, however, adequacy of hemodialysis in AKI patients is not routinely monitor. Methods: This study explored the adequacy of hemodialysis in AKI patients in Bhumibol Adulyadej hospital, Royal Thai Air Force. Delivered Kt/V after each session was calculated using natural logarithm formula with body weight measurement.