“
“Background Acute respiratory

LOXO-101 manufacturer failure due to thyroid compression or invasion of the tracheal lumen is a surgical emergency requiring urgent management. Total thyroidectomy is a routine elective operation, but exceptionally it has to be performed on an emergency basis especially when it is life-threatening due to airway obstruction [1–5]. Laryngo-tracheal compression may be caused by giant or cervico-mediastinal goiter, acute intra-thyroidal hemorrhage, anaplastic carcinoma, lymphoma, and metastases from breast, lung, gastro-enteric and renal cancer [6–12]. Bilateral recurrent laryngeal nerve infiltration by anaplastic cancer, lymphoma, metastasis can also result in vocal cord palsy with worsening dyspnoea [13]. Hemorrhage in cysts and adenoma of thyroid gland is a common asymptomatic event [6]; On the contrary, massive hemorrhage, check details PI3K inhibitor severe enough to result in acute airway distress is exceptional and more frequently secondary to neck trauma rather than a spontaneous complication of thyroid disease [14–16]. The aim of this paper is to describe a series of six patients treated successfully in the emergency setting with total thyroidectomy because of ingravescent dyspnoea and asphyxia, as well as review related data reported in literature. Methods During 2005-2010, of 919 patients treated by total thyroidectomy at our Academic Hospital, 6 (0.7%; 4 females and 2 men, mean age: 68.7 years,

range 42-81 years) were treated in emergency. All the emergency operations were performed for life-threatening respiratory Ergoloid distress, and by the same surgeon (M.T.) with high level of thyroid surgical skill. The

clinical picture at admission, clinical features, type of surgery, outcomes and complications are described below. Mean duration of surgery was 146 minutes (range: 53-260). Case 1 An 81-year-old woman with dyspnoea, tachypnea, stridor, tachycardia, one week history of progressively increasing degree of breathlessness, and a 4-year history of anterior-lateral neck swelling came to our unit. Oxygen therapy was immediately set up, and an urgent CT scan of the neck (Figure 1) showed a huge multinodular goiter with retrosternal extension, producing left displacement of the trachea and its marked narrowing in laterolateral diameter. Because of rapidly worsening respiratory distress, an awake fiberoptic intubation using a small endotracheal tube, followed by induction of general anesthesia and emergency total thyroidectomy by manubriotomy were performed (Figure 2). Intraoperative surgical dissection helped by loupe magnification [17] revealed a mass adherent to the right common carotid artery and extending into the upper mediastinum. It also confirmed the marked left displacement of the trachea and permitted bilateral parathyroid gland and recurrent laryngeal nerve identification. Recovery showed a successfully treated atrial fibrillation and dysphonia due to a left vocal cord palsy confirmed by laryngoscopy.