The rationale is based on stimulatory action exerted by TSH on thyroid cell proliferation and/or progression of a pre-existing papillary carcinoma. To validate this hypothesis, we performed a meta-analysis comparing the incidence of thyroid cancer in 2 groups of patients who underwent surgery for toxic or nontoxic nodular

goiter.

Methods: Using data from 2,150 patients with toxic multinodular goiter (TMNG) and 873 patients with toxic adenoma (TA), the overall incidence of thyroid cancer (and 95% confidence interval [CIs]) was estimated to be 5.9% (3.9 to 8.3) for patients with TMNG and 4.8% (2.5 to 7.9) for patients with TA. Four studies were included in the meta-analysis with a total of 1,964 subjects undergoing thyroidectomy for allegedly benign thyroid disease (520 patients with TMNG or TA and 1,444 for multinodular goiter [MNG] or uninodular goiter [UNG]).

Results: We did not find any significant Blebbistatin differences in the risk of incidental thyroid cancer (ITC) in patients with TMNG versus MNG (odds ratio [OR]: 0.91, 95% CI: 0.47 to 1.77, I-2: 62.6%), TA

versus uninodular goiter (UNG) (OR: 0.46, 95% CI: 0.12 to 1.79, I-2: 12%), and TMNG or TA versus MNG or UNG (pooled analysis) (OR: 0.86, 95% CI: 0.46 to 1.60, I-2: 51.5%).

Conclusions: The results of this meta-analysis did not confirm an association between low TSH values and lower thyroid cancer rate, at least in patients with nodular disease.”
“Objectives: Surgical approaches for

epidermoid cysts of the cerebellopontine angle (CPA) are dictated by tumor location. HKI-272 inhibitor Previous reports have advocated the sacrifice of usable hearing to achieve maximal tumor resection in a single click here operation. The aim of the current study is to demonstrate the applicability of hearing preservation approaches in the neurotologic management of epidermoids of the CPA.

Study Design: Retrospective chart review.

Methods: A search of archived surgical cases at a single institution between January 1, 1997, and December 31, 2011, revealed 18 cases of epidermoid cysts involving the CPA.

Results: Eighteen patients with a mean age 40.9 years underwent surgery. Average tumor size was 4.47 cm, and presenting symptoms included headache, vertigo, cranial neuropathies, and seizures. Thirteen patients underwent a retrosigmoid approach, 2 translabyrinthine, 2 pterional, and 1 retrolabyrinthine/presigmoid. Complications included CSF leak, pseudomeningocele, meningitis, cranial nerve dysfunction, and persistent imbalance. All but 5 patients had long-term follow-up imaging to chronicle tumor residua/recurrence, varying from 6 to 149 months postoperatively. The average length of follow-up was 71.4 months, and residual tumor was common, with most patients demonstrating a focal or small area of residual tumor on follow-up imaging. Two patients had undergone previous surgery for epidermoid excision elsewhere.