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response of breast cancer based on clinical pathological variables. Breast Cancer Res Treat 2009, 117:325–331.PubMedCrossRef 25. Shariat SF, Karakiewicz PI, Suardi N, Kattan MW: Comparison of nomograms with other methods for predicting outcomes in prostate cancer: a critical analysis of the literature. Clin Cancer Res 2008, 14:4400–4407.PubMedCrossRef 26. Abbott J: Pelvic pain: lesson from anatomy and physiology. J Emerg Med 1990, 8:441–447.PubMedCrossRef 27. Lamvu G, Steege JF: The anatomy and neurophysiology of pelvic pain. J Minim Invasive Gynecol 2006, 13:516–522.PubMedCrossRef 28. Houry D, Abbott JT: Ovarian torsion: a fifteen-year review. Ann Emerg Med Molecular motor 2001, 38:156–159.PubMedCrossRef 29. Milholland AV, Wheeler SG, Heieck JJ: Medical assessment by a Delphi group opinion technic. N Engl J Med 1973, 288:1272–1275.PubMedCrossRef Competing interest The authors declare that they have no competing interests. Authors’ contributions CH and AF wrote the manuscript. AF, AD and BF designed the study. AAC, CH and AF collected the datas. CH, AD and AF performed the statistical analysis.”
“Diagnosis and treatment of perforated peptic ulcer (Dr. S. Di Saverio MD) Introduction Every year peptic ulcer disease (PUD) affects 4

milion people around the world [1]. Complications are encountered in 10%-20% of these patients and 2%-14% of the ulcers will perforate [2, 3]. Perforated peptic ulcer (PPU) is relatively rare, but life-threatening with the mortality varying from 10% to 40% [2, 4–6]. More than half of the cases are female and they are usually older and have more comorbidities than their male counterparts [6]. Main etiologic factors include use of non-steroidal anti-inflammatory drugs (NSAIDs), steroids, smoking, Helicobacter pylori and a diet high in salt [3, 7]. All these factors have in common that they affect acid secretion in the gastric mucosa. Defining the exact etiological factor in any given patient may often be Copanlisib clinical trial difficult, as more than one risk factor may be present and they tend to interact [8].

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