The stabilized water content of grains showed a strong association with final grain weight (r(2)=0.88, P < 0.01). Grain length was found to be the trait that best correlated with final grain weight (r(2)=0.98, P < 0.01) and volume (r(2)=0.94, P < 0.01). The main events that defined final grain weight occurred during the first third of selective HDAC inhibitors grain-filling when maternal tissues (the pericarp of grains) undergo considerable expansion. Eight expansin coding sequences were isolated from pericarp RNA and the temporal profiles of accumulation of these transcripts were monitored. Sequences showing high homology with TaExpA6 were notably abundant during early grain expansion and declined as maturity was reached. RNA

in situ hybridization studies revealed that the transcript for TaExpA6 was principally found in the pericarp during early growth in grain development and, subsequently, in both the endosperm and pericarp. The signal in these images is likely to be the sum of the JAK inhibitor transcript levels of all three sequences with high similarity to the TaExpA6 gene. The early part of the expression

profile of this putative expansin gene correlates well with the critical periods of early grain expansion, suggesting it as a possible factor in the final determination of grain size.”
“The paper deals with the assessment of the surface modification of glossy continuous poly( ethylene terephthalate) fibers from the point of view of changes in their surface structure in terms of its micro-topography and the molecular and supermolecular structure of the filament surface layers. The performed SEM and AFM investigations

have shown differences in the fiber surface carving before and after modification ( smoothing or increased roughness), depending on the type of applied enzymatic preparation. Measurements with the use of the ATR-IR method have shown changes in the physicochemical character of the investigated fiber surface. The cleavage of the ester bonds in PET macromolecular chains, resulting from the modifications used, leads to the formation of reactive -OH and -COOH groups. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 3117-3126, 2011″
“Background: Growth kinetic of Plasmodium falciparum in culture or in the host fall short of expected growth rate considering MLN8237 that there are 4 x 10(6)/mu L red blood cell (RBCs) available for invasion and about 16 merozoites growing in each infected RBC. This study determined whether apoptotic machinery is operable to keep the parasite population under check.

Methods: A synchronized culture of P. falciparum (Dd2 strain) was initiated at 0.5% ring stage parasitaemia and kept under conditions not limiting for RBCs and nutrient by adjusting hematocrit to 5% at each schizogony and changing growth media daily. Parasite growth pattern and morphology was evaluated by blood smear microscopy and flow-cytometry using SYBR green.

In this review, we propose an optimized translational research strategy to overcome some

of the major limitations in biomarker discovery. We are confident that early transfer and integration of data between both species, ideally leading to mutual supportive evidence from both preclinical and clinical studies, are most suitable to address some of the obstacles of current depression research.”
“The aim of this study was to determine the influence of the N-isopropyl-N’-phenyl-p-phenylenediamine (IPPD) antioxidant agent on degradation of composites NBR/SiO(2). The inhibition of the early stages of the degrading process has been particularly analyzed.

Several NBR-SiO(2) JPH203 in vivo matrix samples with and without IPPD have been exposed to an oxidizing atmosphere at 140 degrees C for periods between 0 and 120 h. Besides, IPPD alone has been Subject to the same aging thermo-oxidizing process. The degraded samples have been characterized by ATR-FTIR, TG, and SEM. Mechanical properties buy CA3 and degree of crosslinking have been determined. The results show that the IPPD improves the mechanical behavior of the composites submitted to thermo-oxidization, increasing the time in which composite retains rather good mechanical properties. IPPD decreases

the ability of crosslinking of the rubber. ATR-FTIR spectroscopy study shows that the degradation process increases the volatility of the plasticizer and generates new unsaturation sites, which later will be the nuclei of crosslinking. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 114: 2011-2018, 2009″
“P>Seed development

passes through developmental phases such as cell division, differentiation and maturation: each have specific metabolic demands. The ubiquitous sucrose non-fermenting-like kinase (SnRK1) coordinates and adjusts physiological and metabolic demands with growth. In protoplast assays sucrose deprivation and hormone supplementation, such as with auxin and abscisic acid (ABA), stimulate SnRK1-promoter activity. This indicates regulation by nutrients: hormonal crosstalk under conditions of nutrient demand and cell proliferation. GSK690693 concentration SnRK1-repressed pea (Pisum sativum) embryos show lower cytokinin levels and deregulation of cotyledonary establishment and growth, together with downregulated gene expression related to cell proliferation, meristem maintenance and differentiation, leaf formation, and polarity. This suggests that at early stages of seed development SnRK1 regulates coordinated cotyledon emergence and growth via cytokinin-mediated auxin transport and/or distribution. Decreased ABA levels and reduced gene expression, involved in ABA-mediated seed maturation and response to sugars, indicate that SnRK1 is required for ABA synthesis and/or signal transduction at an early stage. Metabolic profiling of SnRK1-repressed embryos revealed lower levels of most organic and amino acids.

The incremental cost-effectiveness of CT colonography with CAD compared with CT colonography without CAD was $8661 and $61 354 per life-year gained for inexperienced and experienced readers, respectively. Optical colonoscopy was not a cost-effective alternative to CT colonography with CAD performed by experienced readers, with an incremental cost-effectiveness of $498 668 per life-year gained. CT colonography with CAD for inexperienced

readers was more clinically effective and cost-effective check details than FS. At analysis, sensitivity of CT colonography with CAD for polyps 6 mm or larger was the most meaningful variable.

Conclusion: The addition of CAD to CT colonography screening improves the CRC prevention rate, resulting in advantageous cost-effectiveness LY2157299 for screening. (C) RSNA, 2009″
“Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the

JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter region of SOCS-3 and rheumatoid arthritis (RA) in a Chinese Han population. Two single-nucleotide polymorphisms in the SOCS-3 5′ region: -1044 C>A within the promoter region and rs12953258 (-920 C>A) in the 5′UTR (exon 2) of SOCS-3 were studied by restriction fragment length polymorphism analysis and tetra-ARMS-PCR in 100 RA patients and 100 healthy adults.

The prevalence of the homozygous genotype -1044 CC was 100% in both RA and control groups. The heterozygous genotype (-920 C>A) was present in 89% of RA and in 82% of the control group, which is significantly different from the distribution signaling pathway in Western people. There was no transmission disequilibrium between these two SNPs (r(2) = 0.000). We did not detect significant differences in allele or genotype frequencies for either of these SNPs between the RA group and controls (P > 0.05). There was no association between rheumatoid factor and SOCS-3 SNP rs12953258 (P = 0.258). We conclude that SOCS-3 polymorphism is not a genetic risk factor for RA in Chinese patients.”
“Campylobacter jejuni is a worldwide foodborne pathogen recognized as a leading cause of human gastrointestinal enteritis. A rapid, sensitive, and specific method is required to monitor food and water in cases of contamination by this pathogen. This report presents a novel immunochromatographic test (ICT) using fluorescent microspheres labeled with polyclonal antibodies of C. jejuni as the capture reagent dispensed onto the conjugate pad. Polyclonal antibodies against the outer membrane protein PEB1 of C. jejuni were used as the detective reagent at the test line, whereas the goat anti-rabbit IgG was used on the control line. PEB1 was obtained by gene cloning and expression to prepare its antibody.

Conclusions. Up to 10 drinks of alcohol per week appears to be safe with respect to the risk for AF in hypertensive patients with LVH. Our data suggest that alcohol intake above this level may be marginally deleterious, while no effect of smoking on risk of AF was detected in hypertensive patients with LVH.”
“Bariatric surgery is increasingly being performed and

sleeve gastrectomy (SG) has proved to be effective and safe. Among its complications, leaks are the most serious and life threatening.

The focus of the study is nine patients who underwent a SG and developed Compound C a gastric leak after surgery. Our data were obtained from the clinical charts of the patients and through interviews with the surgeon who performed the index surgery.

Eight patients underwent SG at outside institutions while one was operated at Clinica Alemana. Three patients developed symptoms within 5 days after surgery, while the rest were diagnosed after 10 days from the surgery. A CT scan was the method used to confirm the diagnosis in all patients. The three patients who had a leak detected during

the immediate postoperative period underwent laparoscopic reoperation. Among the rest of the patients, percutaneous JQ-EZ-05 drainage was employed in one patient as the primary procedure while the other underwent surgical drainage. An esophageal endoluminal stent was employed in four patients. The leak closed in all patients with the healing time ranging from 21 to 240 days.

Diagnosis of a leak after a SG required a greater index of suspicion in order to perform an early diagnosis. Sepsis control and nutritional support are the cornerstones of this treatment. Evolution is characterized by longer periods of time that are necessary in order to wait until the leak closes. Management must be tailored to each patient.”
“Aims: To investigate the therapeutic

effects of repeated detrusor onabotulinumtoxinA injections on urinary incontinence and renal function in patients with chronic spinal cord S63845 research buy injuries (SCI). Methods: Patients with suprasacral SCI were enrolled. OnabotulinumtoxinA 200 U detrusor injections were repeated every 6 months for four times. Patients were instructed to perform clean intermittent catheterization during the treatment and follow-up periods. Videourodynamic study and 99mTc-DTPA renal scanning for glomerular filtration rate (GFR) were performed at screening and every 3 months to assess the therapeutic effects on bladder and renal function. Quality of life was measured by the UDI-6, IIQ-7, and self-assessed QoL indices. Adverse events were also recorded. Results: A total of 33 patients completed the study, 30 had improvement in incontinence grade (n = 18) or became completely dry (n = 12) after initial and subsequent onabotulinumtoxinA injections. Mean bladder capacity increased from 207 +/- 111 to 412 +/- 33 ml and mean detrusor pressure decreased from 39.8 +/- 21.7 to 20.6 +/- 19.1 cmH(2)O (all P < 0.05). However, the mean GFR decreased from 93.

Results: Oraqix (R) was significantly better than nothing, with a reduction of VAS score to 13.3 units, but without significant differences with Vaseline or Hurricaine (R). Oraqix (R) was better in VRS reduction than not using any anesthetic (p=0.001) or using vaseline (p=0.024), but similar to Hurricaine (R) (p=0.232).

Conclusions: Oraqix (R) effectively controls pain in SRP procedures, with few side-effects and a good acceptance on the part of patients and clinicians.”
“Objective. Predict long-term adjustment (pain intensity, pain-related catastrophizing, and pain-related disability) from socio-demographic,

selleck inhibitor claim process, and post-settlement adjustment variables in a cohort of 374 Workers’ Compensation low back claimants.

Methods. Age-and gender-matched subsamples of African Americans and Caucasians were randomly selected for long-term follow-up (6 years post-settlement) from a larger, existing cohort of Workers’ Compensation low back claimants in Missouri. Computer-assisted telephone interviews

were used to assess pain, catastrophizing, and disability. Path VS-6063 order analysis and logistic regression analysis were used to predict long-term adjustment from socio-demographic variables (race, gender, age, and socioeconomic status), Workers’ Compensation claim process variables (surgery, diagnosis, claim duration, treatment costs, settlement awards, and disability rating), and adjustment at baseline.

Results. Poorer long-term adjustment (higher levels of pain, catastrophizing, and pain-related disability) was significantly predicted selleck kinase inhibitor by relatively poorer adjustment at baseline, lower socioeconomic status, and African American race. African American race associations were also mediated through

lower socioeconomic status. Higher levels of occupational disability, as measured by long-term rates of unemployment and social security disability, were also predicted by African American race (in addition to age and claim process factors).

Conclusion. Long-term adjustment to low back pain in this cohort of Workers’ Compensation claimants was stable, relative to short-term adjustment soon after settlement. Long-term adjustment was worse for people of lower socioeconomic status, particularly for economically disadvantaged African Americans, suggesting the possibility of race-and class-based disparities in the Workers’ Compensation system.”
“Hypothesis: We hypothesize that surface landmarks surrounding the round window typically used to guide electrode placement during cochlear implantation (CI) exhibit substantial variability with respect to intracochlear anatomy.

Background: Recent publications suggest that both atraumatic electrode insertion and electrode location within the scala tympani can affect auditory performance after CI.

In study 1056, the effect size for the 600 mg group was moderate-to-large (0.73). selleckchem In study 1077, the effect size for the 600 mg group was large (0.82).

Conclusion: These results provide evidence of the reproducibility, convergent validity, and responsiveness to treatment of the Sleep Quality Scale and provide a foundation for its further use and evaluation in FM patients.”
“Objective. In many parts of Europe, nephropathia epidemica (NE) is an endemic zoonosis. After a flu-like prodrome, this viral disease often manifests with acute kidney injury. Use of non-steroidal anti-inflammatory drugs is discouraged

during the disease, but no data from clinical investigations are available on the association between disease course and the use of analgesics. Material and methods. The charts of 59 patients admitted with NE to a hospital in 2007 were retrospectively analysed. WH-4-023 molecular weight Creatinine levels were compared between users of different analgesics. Results. Patients taking analgesics before admission had higher peak creatinine levels, but not after adjustment for confounders. The subgroup taking ibuprofen or diclofenac had higher initial and peak creatinine levels than the group who did not, even after adjustment for confounders. Conclusion. Since NE cannot be accurately diagnosed in the early disease phase, metamizole, acetaminophen

or acetylsalicylic acid may be preferable analgesics to ibuprofen or diclofenac for flu-like symptoms in endemic areas.”
“The embryonic and postembryonic developmental toxicity of imidazolium-based ionic liquids (ILs) to the snail Physa acuta was evaluated in this study. The results of embryonic toxicity tests showed that lower concentrations of 1-octyl-3-methylimidazolium bromide ([C(8)mim]Br) find more (1.5 and 2.1 mg/L) inhibited the hatching rate of snail embryos, and partial snails hatched normally and died, while all of the treated embryos died when the exposure concentration

was higher than 4.16 mg/L, at which IL caused the deformation, death, and decay of snail embryos. Statistical analyses revealed obvious differences in the hatching rates between three developmental stages in the 2.1 and 2.94 mg/L groups, indicating that the veliger stage is more sensitive to [C(8)mim]Br exposure than the blastula and gastrula stages. Furthermore, the 96 h LC50 values of [C(8)mim]Br on the tested snails at three developmental stages (juvenile, subadult, and adult) were 70.83 +/- 2.99, 97.59 +/- 4.05, and 109.3 +/- 2.22 mg/L, respectively, indicating that young snails were more sensitive to [C(8)mim]Br toxicity than adults. In addition, the 96 h LC50 values of ILs with different alkyl chain lengths, that is, [C(12)mim], [C(10)mim], [C(8)mim], and [C(6)mim], in adult snails were 1.35 +/- 0.24, 8.96 +/- 5.66, 109.3 +/- 4, and 359.6 +/- 11.6 mg/L, respectively, suggesting that longer alkyl chains can increase the toxicity of imidazolium ILs on snails. (c) 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 697-704, 2014.

Methods: Data from 146 subjects High Content Screening with AD and 60 subjects with MCI, as well as 49 HC, was retrospectively analyzed. We used logistic regression analysis with diagnosis as dependent variables and scores of the MMSE, the CDT-command, and the CDT-copy as independent variables, and receiver operating characteristic analysis to distinguish patients with AD from patients with MCI or HC.

Results: When patients with AD were compared to HC, the independent predictors of AD were scores

on the MMSE and the CDT-command. This combination was more sensitive than the MMSE alone and has nearly the same sensitivity and specificity as the ADAS-J cog. When patients with AD were compared to patients with MCI, the independent predictors buy GDC-0973 were the MMSE and the CDT-copy. This combination was more sensitive and specific than the MMSE alone and was almost as sensitive and specific as the ADAS-J cog.

Conclusion: The combination of the MMSE and the CDT could be a powerful screening tool for differentiating between patients with AD, patients with MCI, and HC. Its sensitivity and specificity are comparable to ADAS-J cog, which takes more time.”
“Background: Menopause is a natural physiological event that usually begins in women between the ages of 48 and 55 years. In many cases, this event is

associated with unpleasant somatic-vegetative, urogenital or psychological symptoms.

Objective: To test the health and social demographic factors (especially household income level) that influence willingness to pay (WTP) for a new hormone-free treatment in

women of menopausal age.

Methods: 1365 Pitavastatin cell line women between the ages of 45 and 73 years were surveyed about their health and WTP for the new treatment. WTP was evaluated with a closed-ended binary questionnaire (four groups with different levels of co-payment between is an element of 15 and is an element of 60), using the contingent valuation method. The average WTP was calculated according to the area under the demand function. Factors contributing to payment readiness were examined by means of binary logistic regression.

Results: WTP was significantly affected by women’s opinion of the new medication, the level of co-payment required, net household income, whether currently in treatment for menopausal symptoms, and Menopause Rating Scale (MRS) values. Compared with other factors, the level of co-payment was predicted to have a negative impact on WTP. Income level is an important factor in WTP and correlates highly with several other health-related variables (WHO-5 index, MRS value, receipt of other menopause medicines and existing co-morbidity).

One blastomere was biopsied from day-3 embryos and analysed for chromosomes XY, 13, 15, 16, 17, 18, 21, and 22. From the testing of 1549 embryos, the proportion of chromosomally abnormal embryos was significantly lower in normozoospermic patients (55%) than in OAT (62%, P < 0.025)

and NOA patients (69%, P < 0.005). Complex abnormalities were the most frequent defect in NOA (68%), which also demonstrated the highest incidence of gonosomal aneuploidy (12%). From the re-analysis of all blastomers in 493 non-transferred embroys, 95% of NOA embryos were chaotic mosaics. In conclusion, a severe male infertility condition could contribute to the generation of chromosomal abnormalities in the resulting embryos. This might occur especially in NOA patients in which the high incidence of chromosomal abnormalities is mainly due to mosaicism Selleckchem CB-839 and gonosomal aneuploidy.”
“Purpose

The combination of gemcitabine and docetaxel (GD) is used to effectively treat patients with soft tissue sarcoma (STS). It is widely considered that the conventional doses used are too high for long term use and many patients must discontinue GD treatment due to its toxicity. selleck chemical Therefore, to determine the appropriate dose meeting acceptable efficacy results, while minimizing toxic side effects,

we treated patients with a weekly infusion of GD (weekly GD).

Materials and Methods

A total of 22 patients presenting a variety of STSs were treated at check details Yonsei Cancer Center. All patients had metastatic or recurrent cancer and had previously received doxorubicin and ifosfamide combination chemotherapy. In all cases, gemcitabine (1,000 mg/m(2)) and docetaxel (35 mg/m(2)) were administered intravenously on days 1 and 8 of a 21-day cycle. We retrospectively reviewed the medical records of these patients.

Results

The response rate was 4.5%, with one patient diagnosed with leiomyosarcoma having a partial response, and the disease control rate was 40.9%. The median progression-free

survival (PFS) duration was 2.7 months and the PFS was correlated with the treatment response to a weekly GD. The median overall survival (OS) duration was 7.8 months and the OS was correlated with histology. There was no significant difference in OS between patients who received weekly GD as a 2nd line chemotherapy and those who received 3rd line or more. Treatment was generally well tolerated.

Conclusion

Weekly GD was well tolerated and showed moderate efficacy, indicating that this could be a reasonable option as a salvage treatment for metastatic STS.”
“BackgroundDilated cardiomyopathy (DCM), which is characterized by left ventricular enlargement and systolic dysfunction, is divided into cases with a clear predisposing condition (eg, hypothyroidism, chemotherapeutic agents, alcoholism, ischemia) and those of unknown cause (idiopathic DCM).

“
“Objective. To determine prevalence and risk factors of pregnancy-related lumbopelvic pain (PRLPP) in women in Kuwait. Design. The study NVP-BSK805 was designed as a multisite, cross-sectional design in which self-administered surveys were distributed. Setting and Participants. Public locations and health care facilities in Kuwait. Pregnant women (400) were invited to participate. Outcome Measures.

Demographics, history of PRLPP, risk factors for PRLPP, location of pain, absenteeism due to LPP, management of previous LPP, and functional disability due to PRLPP. Results. Two hundred eighty questionnaires were returned. Mean age was 29.5 years; mean body mass index (BMI) was 29.69 kg/m2. Of the participants, 91% reported LPP, 78.8% reported history of menstrual pain, and 58.7% reported previous LPP, and 59% reported PRLPP during previous pregnancies, 42.8% reported activities of daily living were limited. Risk factors included a history of back pain (P = 0.00), PRLPP in a previous pregnancy (P = 0.01), and being in the third trimester of pregnancy (P = 0.02). BMI was not

associated with PRLPP. Conclusions. Clinicians in Kuwait need to screen for risk factors and detect PRLPP early and intervene as needed. Although overweight and obesity may not contribute largely to PRLPP in women in Kuwait, weight control is a major concern for healthy pregnancy. Physical therapy has a role TGF-beta inhibitor in preventing and addressing this condition.”
“SETTING: CA3 cost Treatment outcomes for multidrug-resistant tuberculosis (MDR-TB) in South Africa

have suffered as centralized, in-patient treatment programs struggle to cope with rising prevalence and human immunodeficiency virus (HIV) co-infection rates. A new treatment model is needed to expand treatment capacity and improve MDR-TB and HIV outcomes.

OBJECTIVE: To describe the design and preliminary results of an integrated, home-based MDR-TB-HIV treatment program created in rural KwaZulu-Natal.

METHOD: In 2008, a decentralized center was established to provide out-patient MDR-TB and HIV treatment. Nurses, community health workers and family supporters have been trained to administer injections, provide adherence support and monitor adverse reactions in patients’ homes. Physicians assess clinical response, adherence and the severity of adverse reactions to MDR-TB and HIV treatment at monthly follow-up visits. Treatment outcomes are assessed by monthly cultures and CD4 and viral load every 6 months.

RESULTS: Of 80 patients initiating MDR-TB treatment from February 2008 to April 2010, 66 were HIV-co-infected. Retention has been high (only 5% defaults, 93% of visits attended), and preliminary outcomes have been favorable (77% cured/still on treatment, 82% undetectable viral load). Few patients have required escalation of care (9%), had severe adverse events (8%) or died (6%).

The Atomic Force Microscopy (AFM) and Scanning Electron Microscopy (SEM) images showed the growing of poly (N-isopropylacrylamide) chains on polyaniline

backbone. Investigation of thermal behavior of graft copolymers by thermal gravimetry analysis (TGA) confirmed the results obtained from AFM and SEM images. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 123: 2299-2308, 2012″
“DNA double-strand breaks (DSBs) pose one of MK-0518 the most severe threats to genome integrity, potentially leading to cell death. After detection of a DSB, the DNA damage and repair response is initiated and the DSB is repaired by non-homologous end joining and/or homologous recombination. Many components of these processes are still unknown in Arabidopsis thaliana. In this work, we characterized gamma-irradiation and mitomycin C induced 1 (GMI1), a member of the SMC-hinge domain-containing protein family. RT-PCR

analysis and promoter-GUS fusion studies showed that gamma-irradiation, the radio-mimetic drug bleocin, and the DNA cross-linking agent mitomycin C strongly enhance GMI1 expression particularly in meristematic tissues. The induction of GMI1 by gamma-irradiation depends on the signalling kinase Ataxia telangiectasia-mutated (ATM) but not on ATM and Rad3-related (ATR). Epistasis analysis of single and double mutants demonstrated that ATM acts upstream of GMI1 while the atr gmi1-2 double mutant was more sensitive than the respective single mutants. Comet assay revealed a reduced rate of DNA double-strand this website GSK923295 inhibitor break repair in gmi1 mutants during the early recovery phase after exposure to bleocin. Moreover, the rate of homologous recombination of a reporter construct was strongly reduced in gmi1 mutant plants upon exposure to bleocin or mitomycin C. GMI1 is the first member of its protein family known to be involved in DNA repair.”
“An adult cohort with tuberous sclerosis complex was investigated for the prevalence of sleep disturbances and the relationship with seizure variables, medication, and psychological functioning. Information on 35 adults was gathered using four

questionnaires: Epworth Sleepiness Scale (ESS), Sleep and Epilepsy Questionnaire (SEQ), Sleep Diagnosis List (SDL), and Adult Self-Report Scale (ASR). In addition, clinical, genetic and electrophysiological data were collected. Of 35 respondents, 25 had a history of epilepsy. A subjective sleep disorder was found in 31% of the cohort. Insomnia scores showed a significant positive correlation with obstructive sleep apnea syndrome and restless legs syndrome scores. Significant correlations were found between daytime sleepiness and scores on depression, antisocial behavior, and use of mental health medication. A subgroup using antiepileptic medication showed high correlations between daytime sleepiness, attention deficits, and anxiety scores. (c) 2010 Elsevier Inc. All rights reserved.”
“Background.